[ Special series on Breast Cancer ]

doi: 10.1186/s40880-017-0202-y

Tumor microenvironment: driving forces and potential therapeutic targets for breast cancer metastasis

Hong-Yan Xie, Zhi-Min Shao and Da-Qiang Li

Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University

[Abstract] Distant metastasis to specific target organs is responsible for over 90% of breast cancer-related deaths, but the underlying molecular mechanism is unclear. Mounting evidence suggests that the interplay between breast cancer cells and the target organ microenvironment is the key determinant of organ-specific metastasis of this lethal disease. Here, we highlight new findings and concepts concerning the emerging role of the tumor microenvironment in breast cancer metastasis; we also discuss potential therapeutic intervention strategies aimed at targeting components of the tumor microenvironment.

Chinese Journal of Cancer 2017, Volume: 36, Issue 3

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Hong-Yan Xie, Zhi-Min Shao and Da-Qiang Li. Tumor microenvironment: driving forces and potential therapeutic targets for breast cancer metastasis. Chin J Cancer. 2017, 36:36. doi:10.1186/s40880-017-0202-y


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