[ Special series on Colorectal Cancer ]
doi: 10.1186/s40880-015-0066-y
Molecular pathogenesis of sporadic colorectal cancers
Hidetsugu Yamagishi, Hajime Kuroda, Yasuo Imai and Hideyuki Hiraishi
Department of Diagnostic Pathology, Dokkyo Medical University
[Abstract] Colorectal cancer (CRC) results from the progressive accumulation of genetic and epigenetic alterations that lead to the transformation of normal colonic mucosa to adenocarcinoma. Approximately 75% of CRCs are sporadic and occur in people without genetic predisposition or family history of CRC. During the past two decades, sporadic CRCs were classified into three major groups according to frequently altered/mutated genes. These genes have been identified by linkage analyses of cancer-prone families and by individual mutation analyses of candidate genes selected on the basis of functional data. In the first half of this review, we describe the genetic pathways of sporadic CRCs and their clinicopathologic features. Recently, large-scale genome analyses have detected many infrequently mutated genes as well as a small number of frequently mutated genes. These infrequently mutated genes are likely described in a limited number of pathways. Gene-oriented models of CRC progression are being replaced by pathway-oriented models. In the second half of this review, we summarize the present knowledge of this research field and discuss its prospects.
Chinese Journal of Cancer 2016, Volume: 35, Issue 1
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Hidetsugu Yamagishi, Hajime Kuroda, Yasuo Imai and Hideyuki Hiraishi. Molecular pathogenesis of sporadic colorectal cancers. Chin J Cancer. 2016, 35:4. doi:10.1186/s40880-015-0066-y
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[ Html full-text / Citation export] (BioMed Central)
[Google Scholar]
[ More articles of the special series on Colorectal Cancer ]
Cite this article
Hidetsugu Yamagishi, Hajime Kuroda, Yasuo Imai and Hideyuki Hiraishi. Molecular pathogenesis of sporadic colorectal cancers. Chin J Cancer. 2016, 35:4. doi:10.1186/s40880-015-0066-y
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