doi: 10.5732/cjc.014.10193

Epstein-Barr virus and the origin of Hodgkin lymphoma

Martina Vockerodt, Fathima Zumla Cader, Claire Shannon-Lowe, Paul Murray

School of Cancer Sciences, University of Birmingham, Birmingham, B15 2TT, the United Kingdom.

[Abstract] Although Epstein-Barr virus (EBV) is present in the malignant Hodgkin/Reed-Sternberg (HRS) cells of a proportion of cases of classical Hodgkin lymphoma (cHL), how the virus contributes to the pathogenesis of this disease remains poorly defined. It is clear from the studies of other EBV-associated cancers that the virus is usually not sufficient for tumor development and that other oncogenic co-factors are required. This article reviews what is known about the contribution of EBV to the pathogenesis of cHL and focuses on emerging evidence implicating chronic inflammation as a potential oncogenic co-factor in this malignancy.

Chinese Journal of Cancer 2014, Volume: 33, Issue 12, Page: 591-597

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Martina Vockerodt, Fathima Zumla Cader, Claire Shannon-Lowe, Paul Murray. Epstein-Barr virus and the origin of Hodgkin lymphoma. Chin J Cancer. 2014, 33(12):591-597. doi:10.5732/cjc.014.10193


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