doi: 10.5732/cjc.012.10218

Skeletal metastasis: treatments, mouse models, and the Wnt signaling

Kenneth C. Valkenburg, Matthew R. Steensma, Bart O. Williams , Zhendong Zhong

Center for Skeletal Disease Research, Van Andel Research Institute, 333 Bostwick Ave. NE, Grand Rapids, MI 49503, USA; 2Orthopedic Oncology, Spectrum Health, 145 Michigan St. NE, Grand Rapids, MI 49503, USA.

[Abstract] Skeletal metastases result in significant morbidity and mortality. This is particularly true of cancers with a strong predilection for the bone, such as breast, prostate, and lung cancers. There is currently no reliable cure for skeletal metastasis, and palliative therapy options are limited. The Wnt signaling pathway has been found to play an integral role in the process of skeletal metastasis and may be an important clinical target. Several experimental models of skeletal metastasis have been used to find new biomarkers and test new treatments. In this review, we discuss pathologic process of bone metastasis, the roles of the Wnt signaling, and the available experimental models and treatments.

Chinese Journal of Cancer 2013, Volume: 32, Issue 7, Page: 380-396

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Kenneth C. Valkenburg, Matthew R. Steensma, Bart O. Williams , Zhendong Zhong. Skeletal metastasis: treatments, mouse models, and the Wnt signaling. Chin J Cancer. 2013, 32(7):380-396. doi:10.5732/cjc.012.10218


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