doi: 10.5732/cjc.012.10084

Regulation of tumor cell migration by protein tyrosine phosphatase (PTP)-proline-, glutamate-, serine-,and threonine-rich sequence (PEST)

Yanhua Zheng, Zhimin Lu

Brain Tumor Center and Department of Neuro-Onco-logy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA

[Abstract] Protein tyrosine phosphatase (PTP)-proline-, glutamate-, serine-, and threonine-rich sequence (PEST) is ubiquitously expressed and is a critical regulator of cell adhesion and migration. PTP-PEST activity can be regulated transcriptionally via gene deletion or mutation in several types of human cancers or via post-translational modifications, including phosphorylation, oxidation, and caspase-dependent cleavage. PTP-PEST interacts with and dephosphorylates cytoskeletal and focal adhesion-associated proteins. Dephos-phorylation of PTP-PEST substrates regulates their enzymatic activities and/or their interaction with other proteins and plays an essential role in the tumor cell migration process.

Chinese Journal of Cancer 2013, Volume: 32, Issue 2, Page: 75-83

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Yanhua Zheng, Zhimin Lu. Regulation of tumor cell migration by protein tyrosine phosphatase (PTP)-proline-, glutamate-, serine-,and threonine-rich sequence (PEST). Chin J Cancer. 2013, 32(2):75-83. doi:10.5732/cjc.012.10084


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